Research summary: eating an egg a day is healthy and more

Every week, many scientific studies are published. Here is an overview of the most interesting.

No risk of heart disease by eating one egg a day

Nutritional science seems to come and go, and for years eating chicken eggs has been considered somewhat unhealthy due to high cholesterol. Science is moving away from this observation. Now researchers with McMaster University‘s Population Research Institute (PHRI) and Hamilton Health Sciences analyzed data of three large multinational long-term studies. And they found no harm in eating eggs. Mahshid Dehghan, lead author and PHRI researcher, noted that the majority of people in the studies ate one egg or less per day and it was clearly safe to consume at that level.

“Moderate egg consumption, which is about one egg per day in most people, does not increase the risk of cardiovascular disease or death, even if people have a history of cardiovascular disease or diabetes.” , Dehghan said. “In addition, no association was found between egg consumption and blood cholesterol, its components or other risk factors. These findings are robust and widely applicable to both healthy individuals and those with vascular disease. “

The studies included egg consumption data from 146,011 people from 21 countries, which were recorded in the PURE study, and in 31,544 vascular disease patients from the ONTARGET and TRANSEND studies. These included populations from 50 countries on six continents at different income levels. The research was published in The American Journal of Clinical Nutrition.

How to turn off liver fibrosis (at least in mice)

Scarring, or fibrosis, of the liver is found in a number of conditions, including chronic alcohol abuse, hepatitis, non-alcoholic steatohepatitis (NASH), and non-alcoholic fatty liver disease (NAFLD). Researchers at the University of California San Diego School of Medicine identified a potential “Stop switch” that could possibly be used to treat these diseases, at least in mice. They found that by manipulating a special population of liver cells called hepatic stellate cells (HSCs), they were able to turn the pathways leading to liver fibrosis on or off.

Researchers have identified the best strategies for maintaining weight loss

California Polytechnic State University researchers published results in the newspaper Obesity which listed the most effective psychological behaviors and strategies to maintain weight loss. They studied 54 behaviors related to weight management and found that the most common among people who were successful in losing and maintaining their weight loss were setting daily food intake goals, keeping a food journal, measure food and stay positive when gaining weight.

Understanding brain connectivity

A new study explored the role of dynamic interactions between different groups of brain cells involved in cognitive function. These types of studies generally fall into three categories, spatial dynamics, temporal dynamics and spatiotemporal dynamics, the third being the least studied. It refers to a combination of changes in the shape, size or location of brain networks and the way brain connections change. Potentially, this new study could lead to changes in the way diseases are modeled in the brain and new ways to apply existing disease models more broadly.

Possible treatment for Duchenne muscular dystrophy

Researchers at the Technical University of Munich (TUM) recently developed gene therapy that could cure DMD. The interdisciplinary team led by researchers from TUM has successfully corrected the mutated dystrophin gene in live pigs. They modified the editing of the CRISPR-Cas9 gene to correct the dystrophin gene. This change made the gene readable by the protein-making machinery in cells. The new dystrophin gene was even shorter than the normal dystrophin gene, but was able to stably form the dystrophin protein, which improved muscle function. In particular, laboratory animals were less susceptible to the cardiac arrhythmia seen in the disease and had an increased life expectancy.

How cells move

Many different types of cells in the body move around, but how was not well understood. For example, if the skin is cut, the cells move to heal the wound. The researchers have find that cells of different shapes, round or elongated, for example, move in different ways. But the apparent commonality is traction. Each cell applies a force to the surface below, which means traction, which is dominant in the way cells move in groups. The new understanding may have implications for how to improve wound healing.

Massive Asians Genome Study Underway

Asian populations are often under-represented in genetic studies, which may have implications for clinical trials and drug development. Researchers from dozens of institutions around the world, including the University of Virginia School of Medicine, are working within the framework of the GenomeAsia 100K Consortium. So far, they have analyzed the genomes of 1,739 people from 219 different population groups in 64 countries in Asia. The goal is to sequence the genomes of 100,000 Asians.


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